What happens if the first packet of a TFTP transfer is lost?

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Question:
What happens if the first packet of a TFTP transfer is lost?

The client will wait indefinitely for the reply.
The TFTP application will retry the request if a reply is not received.
The next-hop router or the default gateway will provide a reply with an error code.
The transport layer will retry the query if a reply is not received.

Explanation: The TFTP protocol uses UDP for queries, so the TFTP application must implement the reliability, if needed.